2018 | Month: | Volume:5 | Issue:1 | Page:30-38

The influence of salivary pH and calcium/phosphate ions concentration on salivary gland stones' formation

Stasikelyte Morta, Kireilyte Mante, Baniene Rasa, Januzis Gintaras

Background: Sialolithiasis is a multi-factorial pathology that accounts for more than 50% of salivary gland disease. However, the exact impact of salivary pH and calcium (Ca2+) and phosphate (PO43−) on the sialoliths' formation still remains unknown. 

Materials and Methods: Seven  removed sialoliths were put into flasks with artificial saliva solution that differed in concentrations of Ca2+ and PO43−. The changes in weights of sialoliths and alterations in pH had been measured for 13 weeks. Concentrations of Ca2+ and PO43− in the artificial saliva solution were estimated at the beginning and at the end of the experiment.

Results: Sialoliths' weight decrease was observed from the 2nd to 7th week. It occurred parallel with natural pH decrease (from 7 to 6.5 pH). Sialoliths’ weights started increasing after pH was adjusted with NaOH. Analyzing the concentration changes of Ca2+ in every flask, it was determined that from natural or double Ca2+ concentration, it decreased till similar amount (7–14 times). Analyzing the concentration changes of PO43−, it was determined that from natural or double PO43− concentration it decreased 24 times.

Conclusions: Sialoliths' weights decreased parallel with natural pH decrease and sialoliths  grew when pH was adjusted. PO43− ions concentration decreased relatively more than Ca2+ ions concentration.

Abstracting, Indexing and Library Catalogued Information

Indexing in other databases in progress.