2015 | Month:December | Volume:2 | Issue:3 | Page:215-221

Liver function tests in first and third trimesters of normal pregnancy in a population of North Kerala

The aim of the study was to compare the first and third trimester variations of liver function tests during normal pregnancy in the age group of 20 to 30 years. It was a comparative prospective study wherein 100 pregnant women attending out-patient department for routine antenatal check-up were included. History was taken and general physical examination, systemic examination, routine investigations and liver functions tests were performed. Liver function tests were performed by an autoanalyzer. Analysis was done using student’s t-test. P-value less than 0.05 was taken as significant. The serum total bilirubin, direct bilirubin, indirect bilirubin, aspartate amino transferase, total protein, albumin, globulin and gamma glutamyl transferase levels were higher in the first trimester when compared to the third trimester. The serum alanine amino transferase and alkaline phosphatase levels were higher in the third trimester when compared to the first trimester. There was not much significant difference between the A/G ratio and serum prothrombin levels in first trimester compared to that of third trimester. The decrease in total bilirubin, direct bilirubin, indirect bilirubin, total proteins, albumin and globulin were due to a phenomenon called hemo-dilution. The decrease in gamma glutamyl transferase could be due to the effect of hormones, oestrogen and progesterone which increases during pregnancy. Alkaline phosphatase levels increase by third trimester due to placental synthesis. Prothrombin time does not show any change in both the trimesters which shows that pregnancy has no effect on prothrombin time.

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